I don't know if it is their intent to make it harder, but if they had a proper camera where you could track the pitch come into the hitter (catcher cam style) then I think I'd be able to hit at 100 Ego. Perhaps not easily, but it would at least be possible. Otherwise it's an entire guessing game. You're not tracking the ball in this game, you're tracking the cursor dot.
Also I'm glad I've always played with right-handed pitchers in this game, because I would hate to have a left-handed pitcher and look over the pitcher's left shoulder as opposed to having the broadcast-like right shoulder that I'm so used to. Having that customizable so that you can keep it over the right side would be ideal if I ever did have a lefty.